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8.1 Introduction
ere has been ever-increasing interest in the development of high-resolution optical imaging of the tis-
sue structure for biological and biomedical applications, both in vitro and in vivo. A special emphasis is
being made on minimally and noninvasive clinical imaging systems for diagnostics and monitoring of
cancers and other disorders. e most recent additions to the clinical tools are optical diusion tomog-
raphy methods based on the measurement of scattering, absorption, and uorescence from the tissue
over a depth of a few centimeters [1]. e main drawback of these methods is their little specicity due to
low resolution ...