Chapter 8
Further methods
Three further methods are briefly discussed in this chapter: i) toxicokinetics, ii) toxicoge-nomics, and iii) interlaboratory studies.
8.1 Toxicokinetics
According to the ICH guideline S3A [332] toxicokinetic methods characterize the systemic exposure achieved in animals and its relation to dose and time in repeated toxicity studies.
Features:
- Toxicokinetics: Estimating area-under-the-curve (AUC) for incomplete designs
- Toxicokinetics: Comparing AUCs
- Toxicogenomics: The Benjamini–Hochberg false discovery approach is used for selected probe sets
- Toxicogenomics: Trend tests for high-dimensional data are shown
- Interlaboratory studies: The similarity of the dose-response relationship between laboratories is demonstrated ...
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