
4
Robust Synthetic Biology
Designs based on Network
Evolutionary Methods
4.1 Robust Synthetic Biology Design using GA and EA
In the above robust synthetic gene network designs, we need to solve a set
of LMIs in (3.20). In this chapter, a simple but suffi cient robust synthetic
gene network design method via evolutionary algorithms is introduced. To
mimic the natural selection in evolution in order to select adequate design
parameters for obtaining a robust synthetic gene network with desired
behaviors under intrinsic parameter fl uctuations and extrinsic disturbances
on the host cell, the proposed network evolutionary design method based
on genetic ...