
48 Synthetic Gene Network: Modeling, Analysis, and Robust Design Methods
Figure 4.4. Time-responses of protein concentrations. (a) The nominal repressilator time-
response with
C
i
= 0.5,
I
pi
= 0.069 for i = 1,2,3 by the minute in (Elowitz and Leibler 2000).
(b) The repressilator time-response under intrinsic parameter fl uctuations and extrinsic
disturbances on the host cell. These two time-responses show that the repressilator in (Elowitz
and Leibler 2000) suffers substantially from the effects of intrinsic parameter fl uctuations
and environmental noises on the host cell. Clearly, the corrupted repressilator does not
have enough robustness to ...