()
()
()
()
()
()
12
12
111 2 22
11 2 2
11 2 2
1() 1()
(,,,) , (,,,)
,,
,,
TetR LacI
TetR LacI
Hr Hr
Hr Hr
gXcrt g Xcrt
xct xct
Xct X ct
È˘ È
Í˙
--
Í˙
==
Í˙
Í˙
Í˙
Î˚
()
()
()
()
()
()
34
34
333 444
33 44
33 44
,
1() 1 ()
(,,,) , (,,,)
,,
,,
CI TetR
CI TetR
Hr H r
Hr H r
gXcrt gXcrt
xct xct
Xct Xct
˘
Í˙
Í˙
Í˙
Í˙
Í˙
Î˚
È˘
È˘
Í˙
Í˙
--
Í˙
Í˙
==
Í˙
Í˙
Í˙
Í˙
Í˙
Í˙
Î˚
Î˚
with
()
133
,rXct=
,
()
211
,rXct=
,
()
322
,rXct=
and
()
433
,rXct=
.
Suppose the perturbation elements &
D
, &
C
, &
I
,
k
s
c
and
, 1, , 4
k
r
ckΔ=…
of parameter fl uctuation matrices
k
M
in (6.36) to be
tolerated are listed as follows
0.1 , 0.1 , 1, , 4
0.1 , 0.1 , 0.1 ,
kkk k
rrss
cccck
bbaagg
D= ¥ D= ¥ =
D= ¥ D= ¥ D= ¥
…
(6.37)
Since there is currently no CI-regulated promoter library, the promoter
regulation function of c
3
takes the following form (Basu et al. 2005)
()
2
33 3
, 150 ...