197 Self-Immolative Polymers
Self-immolative polymers (SIPs) are a class of degradable polymers characterized by their ability to translate a single-bond cleavage event at the polymer terminus or within the backbone into a cascade of reactions that leads to complete depolymerization (Figure 197.1).
The origins of self-immolative macromolecules date back to 1981 when Carl et al. developed a self-immolative “spacer” flanked by a triggering moiety and an “output” molecule (Figure 197.2A). In 2001, Scheeren and coworkers linked multiple spacers together in an iterative fashion and demonstrated a cascade of eliminations to release drug molecules from the terminus of the self-immolative scaffold (Figure 197.2B). This ...
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