For maximum image quality, you should use the highest optical resolution for scanner input—but only if the analog original requires it! With VueScan’s output size reduction feature, you can reduce the scan’s file size in many cases without any effective loss of image quality—as long as you know what you’re doing! Check these factors:
Nominal optical resolution of the scanner (see the scanner packaging)
Effective optical resolution of the scanner (check good reviews like www.filmscanner.info)
Quality of the analog original (this depends on various factors)
Pixel size of the raw data that VueScan uses internally (see Input ‣ Scan resolution and Input ‣ Bits per pixel)
Pixel size of the output file (reduce it with size ...