18.9. In situ Tissue Reconstruction by Injectable Acellular Biomaterials

While the search for a suitable cell source for cardiac tissue engineering and regeneration is ongoing, the potential of biomaterials as an acellular therapeutic strategy has been established and continuously expanded over the last decade or so. As mentioned, adverse remodeling after MI has been associated with excessive damage to the cardiac ECM, which plays a critical role in maintenance, integrity, and function of the heart tissue. These dynamic changes and alterations in cardiac ECM composition have a detrimental effect on both systolic and diastolic function (Akhyari et al., 2008; Dobaczewski et al., 2010). Biomaterials can be designed to mimic cardiac ECM properties, ...

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