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Tissue Engineering Using Ceramics and Polymers, 2nd Edition by P.X. Ma, Aldo R Boccaccini

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8

Transplantation of engineered cells and tissues

J. Mansbridge,    Histogen, Inc., USA

Abstract:

It has long been known that transplantation of organs between different individuals leads to rejection. However, by contrast, implantation of tissue engineered products containing live cells has thus far shown no clinical evidence for immune rejection. Limited testing for specific mechanisms of rejection has shown no evidence of either humoral or cell-mediated reaction to the implants. This chapter discusses mechanisms of the immune response to grafts, the role of antigen-presenting cells and the reasons for this finding. A comparison is made between the autologous and allogeneic approaches to the manufacture of tissue engineered products. Methods ...

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