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Tissue Engineering Using Ceramics and Polymers, 2nd Edition by P.X. Ma, Aldo R Boccaccini

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19

Liver tissue engineering

J. Bierwolf and J.-M. Pollok,    University Hospital Bonn, Germany

Abstract:

Due to the lack of human organs required for liver transplantation, alternative methods including tissue engineering have been established over the last decades. This chapter describes all the relevant elements concerning liver tissue engineering using polymeric scaffolds. The chapter begins with a brief review on liver diseases and current treatments. The special demands, which hepatocytes in three-dimensional culture require, are then reviewed. Furthermore, an overview on tests and assays to analyse hepatocyte-specific function in vitro is given and potential clinical applications using engineered liver tissue are mentioned. Limitations ...

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