Two-Dimensional (2D) NMR Methods

9 Anisotropic One-dimensional/Two-dimensional NMR in Molecular AnalysisContributions and Opportunities of Anisotropic One-dimensional/Two-dimensional NMR to Recent Analysis of Small Organic Molecules

Philippe Lesot^1,* and Roberto R. Gil²

¹ Université Paris-Saclay, RMN en Milieu Orienté, ICMMO, UMR CNRS 8182, Site BPC, Bât. Henri Moissan (HM1), Orsay 91400, France² Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA^*Corresponding Author

9.1 Introduction

Due to its variety of analytical possibilities and methodologies developed over the last three decades in solid or liquid phase, NMR spectroscopy has become a powerful and indispensable tool in modern chemistry [1]. In this chapter, we will address an original aspect of modern NMR dedicated to the analysis of small (achiral, prochiral, and chiral) molecules using (weakly orienting) ordered media as alternative NMR solvents. Interestingly, this approach combines the use of residual anisotropic NMR interactions (tensorial properties) observed in oriented environments (liquid crystals, liquid-crystalline solution, ordered phases) and the spectral advantages of high-resolution liquid-state NMR. In the literature, there are numerous publications describing the analysis of mesogenic molecules forming generally nematics mesophases (thermotropics) or solutes aligned in oriented phases. Without wishing to be exhaustive, the readers may take a look at some “reference” books dealing with this subject [2-7]. In this ...