Ed Penhoet is not a naturally charismatic man, at least until he starts talking about something that matters to him. When he does, his passionate intensity drives a simple eloquence that commands attention.

In the ’70s Ed was a faculty member of the Biochemistry Department of U.C. Berkeley. In 1981, he cofounded Chiron Corporation, made himself into an exceptionally successful entrepreneur and leader, and served as its Chief Executive Officer until 1998. Beginning with the sequencing of the HIV genome in 1984 and the discovery of the Hepatitis C genome in 1987, Chiron has been a consistent leader in making groundbreaking discoveries in the field of medical research.

Toward the end of an interview with him once, I asked Ed what advice he could ...

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