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Domain-Specific Small Language Models
book

Domain-Specific Small Language Models

by Guglielmo Iozzia
May 2026
Intermediate
376 pages
9h 52m
English
Manning Publications

Overview

Bigger isn’t always better. Train and tune highly focused language models optimized for domain specific tasks.

When you need a language model to respond accurately and quickly about a specific field of knowledge, the sprawling capacity of a LLM may hurt more than it helps. Domain-Specific Small Language Models teaches you to build generative AI models optimized for specific fields.

In Domain-Specific Small Language Models you’ll discover:

  • Model sizing best practices
  • Open source libraries, frameworks, utilities and runtimes
  • Fine-tuning techniques for custom datasets
  • Hugging Face’s libraries for SLMs
  • Running SLMs on commodity hardware
  • Model optimization or quantization

Perfect for cost- or hardware-constrained environments, Small Language Models (SLMs) train on domain specific data for high-quality results in specific tasks. In Domain-Specific Small Language Models you’ll develop SLMs that can generate everything from Python code to protein structures and antibody sequences—all on commodity hardware.

About the Technology
Small-footprint language models trained on custom data sets and hosted locally can perform as well as large generalist models in speed and accuracy, often at a fraction of the cost. Domain-Specific Small Language Models shows you how to build privacy-preserving and regulation-compliant SLMs for agentic systems, specialist applications, and deployment on the edge.

About the Book
This is a practical book that shows you how to adapt pretrained open source models to your domain using transfer learning and parameter-efficient fine-tuning. You’ll learn to minimize cost through optimization and quantization, develop secure APIs to serve your models, and deploy SLMs on commodity hardware—including small devices. The hands-on examples include integrating SLMs into RAG systems and agentic workflows.

What's Inside
  • ONNX and other quantization methods
  • Integrate SLMs into end-to-end applications
  • Deploy SLMs on laptops, smartphones, and other devices


About the Reader
For AI engineers familiar with Python.

About the Author
Guglielmo Iozzia is a Director of AI and Applied Mathematics at Merck & Co. and a Distinguished Member of the American Society for Artificial Intelligence. He specializes in AI biomedical applications.

The technical editor on this book was Riccardo Mattivi.

Quotes
A rare combination of conceptual clarity and practical guidance.
- From the Foreword by Matthew R. Versaggi

Gives the reader a jumpstart toward making efficient, focused models with well-controlled data.
- Janelle Shane, AI Weirdness

Effectively cuts through the hype to focus on the tangible business value of localized, efficient artificial intelligence.
- Luca Longo, University College Cork

A timely and much-needed reference for both researchers and industry practitioners.
- Ahmed Serag, Weill Cornell Medicine

Excellent collection of tips and techniques.
- Andrew R. Freed, IBM

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Publisher Resources

ISBN: 9781633436701Publisher SupportOtherPublisher WebsitePurchase Link