Chemometrics for analytical data mining in separation process design for recovery of artemisinin from Artemisia annua

Chandrakant R. Malwade, Haiyan Qu, Ben-Guang Rong and Lars P. Christensen,    Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, DK-5230, Odense M, Denmark; Tel. +45 6550 7481, e-mail: bgr@kbm.sdu.dk

Abstract

In this work, to understand the separation behavior of the flash column chromatography during purification of artemisinin from the crude extract of Artemisia annua, multivariate data analysis technique PARAFAC (Parallel factorization) is used to mine the relevant chemical information from analytical chromatograms of 9 artemisinin containing fractions. The size ...

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