Prediction of biopharmaceutical facility fit issues using decision tree analysis

Yang Yanga, b, Suzanne S. Farida and Nina F. Thornhillb,    aEPSRC Centre for Innovative Manufacturing in Emergent Macromolecular Therapies, Department of Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK, bCentre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK

Abstract

The impact of upstream and downstream process fluctuations in bioprocesses becomes more pronounced during technology transfer of pilot scale processes into large-scale facilities. Mismatches in equipment sizes upon scale-up combined with process fluctuations can lead to ...

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