23rd European Symposium on Computer Aided Process Engineering

A model based approach to an adaptive design space in chromatography

Edward Close^{a, b}, Daniel G Bracewell^b and Eva Sorensen^a,    ^aCPSE, Department of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK. e-mail: [e-mail], ^bACBE, Department of Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.

Abstract

We demonstrate an approach to construct an adaptive design space in the face of process variability, for an industrial hydrophobic interaction chromatography (HIC) with resin lot-to-lot variability. The step has a complex mixture of impurities in the feed stream and a multi component product. The step must deliver a specific distribution of product forms in ...