Advances in Computers

Chapter Three

Overview of Computational Approaches for Inference of MicroRNA-Mediated and Gene Regulatory Networks

Blagoj Ristevski¹    Faculty of Information and Communication Technologies—Bitola, St. Kliment Ohridski University, Bitola, Macedonia¹ Corresponding author: email address: [e-mail]

Abstract

This chapter describes biological backgrounds of regulatory relationships in living cells, high-throughput experimental technologies, and application of computational approaches in reverse engineering of microRNA (miRNA)-mediated and gene regulatory networks (GRNs). The most commonly used models for GRNs inference based on Boolean networks, Bayesian networks, dynamic Bayesian networks, association networks, novel two-stage ...