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Advances in Computers by Atif Memon

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Chapter Three

Overview of Computational Approaches for Inference of MicroRNA-Mediated and Gene Regulatory Networks

Blagoj Ristevski1    Faculty of Information and Communication Technologies—Bitola, St. Kliment Ohridski University, Bitola, Macedonia1 Corresponding author: email address: blagoj.ristevski@uklo.edu.mk

Abstract

This chapter describes biological backgrounds of regulatory relationships in living cells, high-throughput experimental technologies, and application of computational approaches in reverse engineering of microRNA (miRNA)-mediated and gene regulatory networks (GRNs). The most commonly used models for GRNs inference based on Boolean networks, Bayesian networks, dynamic Bayesian networks, association networks, novel two-stage ...

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