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Analysis of Clinical Trials Using SAS, 2nd Edition
book

Analysis of Clinical Trials Using SAS, 2nd Edition

by Alex Dmitrienko, Gary G. Koch
July 2017
Intermediate to advanced content levelIntermediate to advanced
410 pages
14h 36m
English
SAS Institute
Content preview from Analysis of Clinical Trials Using SAS, 2nd Edition

Chapter 1

Model-based and Randomization-based Methods

Alex Dmitrienko (Mediana)

Gary G. Koch (University of North Carolina at Chapel Hill)

1.1 Introduction

1.2 Analysis of continuous endpoints

1.3 Analysis of categorical endpoints

1.4 Analysis of time-to-event endpoints

1.5 Qualitative interaction tests

1.6 References

This chapter discusses the analysis of clinical endpoints in the presence of influential covariates such as the trial site (center) or patient baseline characteristics. A detailed review of commonly used methods for continuous, categorical, and time-to-event endpoints, including model-based and simple randomization-based methods, is provided. The chapter describes parametric methods based on fixed and random effects models as well ...

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Publisher Resources

ISBN: 9781635261448