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Analysis of Clinical Trials Using SAS, 2nd Edition
book

Analysis of Clinical Trials Using SAS, 2nd Edition

by Alex Dmitrienko, Gary G. Koch
July 2017
Intermediate to advanced content levelIntermediate to advanced
410 pages
14h 36m
English
SAS Institute
Content preview from Analysis of Clinical Trials Using SAS, 2nd Edition

Chapter 4

Dose-finding Methods

Srinand Nandakumar (Pfizer)

Alex Dmitrienko (Mediana)

Ilya Lipkovich (QuintilesIMS)

4.1 Introduction

4.2 Case studies

4.3 Dose-response assessment and dose-finding methods

4.4 Dose finding in Case study 1

4.5 Dose finding in Case study 2

4.6 References

The chapter introduces a family of statistical methods used in Phase II trials to study the relationship between the dose of an experimental treatment and clinical response. This includes methods aimed at testing the dose-response trend; estimating the underlying dose-response function; and identifying a dose or set of doses to be examined in the subsequent confirmatory trials. Powerful methods for detecting dose-response signals use one or more contrasts that evaluate ...

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Publisher Resources

ISBN: 9781635261448