Book description
This book is designed to introduce biologists, clinicians and computational researchers to fundamental data analysis principles, techniques and tools for supporting the discovery of biomarkers and the implementation of diagnostic/prognostic systems.
The focus of the book is on how fundamental statistical and data mining approaches can support biomarker discovery and evaluation, emphasising applications based on different types of "omic" data. The book also discusses design factors, requirements and techniques for disease screening, diagnostic and prognostic applications.
Readers are provided with the knowledge needed to assess the requirements, computational approaches and outputs in disease biomarker research. Commentaries from guest experts are also included, containing detailed discussions of methodologies and applications based on specific types of "omic" data, as well as their integration. Covers the main range of data sources currently used for biomarker discovery
Covers the main range of data sources currently used for biomarker discovery
Puts emphasis on concepts, design principles and methodologies that can be extended or tailored to more specific applications
Offers principles and methods for assessing the bioinformatic/biostatistic limitations, strengths and challenges in biomarker discovery studies
Discusses systems biology approaches and applications
Includes expert chapter commentaries to further discuss relevance of techniques, summarize biological/clinical implications and provide alternative interpretations
Table of contents
- Cover
- Title page
- Copyright
- Dedication
- Author and guest contributor biographies
- Acknowledgements
- Preface
-
1: Biomarkers and bioinformatics
- 1.1 Bioinformatics, translational research and personalized medicine
- 1.2 Biomarkers: fundamental definitions and research principles
- 1.3 Clinical resources for biomarker studies
- 1.4 Molecular biology data sources for biomarker research
- 1.5 Basic computational approaches to biomarker discovery: key applications and challenges
- 1.6 Examples of biomarkers and applications
- 1.7 What is next?
-
2: Review of fundamental statistical concepts
- 2.1 Basic concepts and problems
- 2.2 Hypothesis testing and group comparison
- 2.3 Assessing statistical significance in multiple-hypotheses testing
- 2.4 Correlation
- 2.5 Regression and classification: basic concepts
- 2.6 Survival analysis methods
- 2.7 Assessing predictive quality
- 2.8 Data sample size estimation
- 2.9 Common pitfalls and misinterpretations
- 3: Biomarker-based prediction models: design and interpretation principles
-
4: An introduction to the discovery and analysis of genotype-phenotype associations
- 4.1 Introduction: sources of genomic variation
- 4.2 Fundamental biological and statistical concepts
- 4.3 Multi-stage case-control analysis
- 4.4 SNPs data analysis: additional concepts, approaches and applications
- 4.5 CNV data analysis: additional concepts, approaches and applications
- 4.6 Key problems and challenges
- Guest commentary on chapter 4: Integrative approaches to genotype-phenotype association discovery
- 5: Biomarkers and gene expression data analysis
- Guest commentary on chapter 5: Advances in biomarker discovery with gene expression data
-
6: Proteomics and metabolomics for biomarker discovery: an introduction to spectral data analysis
- 6.1 Introduction
- 6.2 Proteomics and biomarker discovery
- 6.3 Metabolomics and biomarker discovery
- 6.4 Experimental techniques for proteomics and metabolomics: an overview
- 6.5 More on the fundamentals of spectral data analysis
- 6.6 Targeted and global analyses in metabolomics
- 6.7 Feature transformation, selection and classification of spectral data
- 6.8 Key software and information resources for proteomics and metabolomics
- 6.9 Gaps and challenges in bioinformatics
- Guest commentary on chapter 6: Data integration in proteomics and metabolomics for biomarker discovery
-
7: Disease biomarkers and biological interaction networks
- 7.1 Network-centric views of disease biomarker discovery
- 7.2 Basic concepts in network analysis
- 7.3 Fundamental approaches to representing and inferring networks
- 7.4 Overview of key network-driven approaches to biomarker discovery
- 7.5 Network-based prognostic systems: recent research highlights
- 7.6 Final remarks: opportunities and obstacles in network-based biomarker research
- Guest commentary on chapter 7: Commentary on ‘disease biomarkers and biological interaction networks’
-
8: Integrative data analysis for biomarker discovery
- 8.1 Introduction
- 8.2 Data aggregation at the model input level
- 8.3 Model integration based on a single-source or homogeneous data sources
- 8.4 Data integration at the model level
- 8.5 Multiple heterogeneous data and model integration
- 8.6 Serial integration of source and models
- 8.7 Component- and network-centric approaches
- 8.8 Final remarks
- Guest commentary on chapter 8: Data integration: The next big hope?
-
9: Information resources and software tools for biomarker discovery
- 9.1 Biomarker discovery frameworks: key software and information resources
- 9.2 Integrating and sharing resources: databases and tools
- 9.3 Data mining tools and platforms
- 9.4 Specialized information and knowledge resources
- 9.5 Integrative infrastructure initiatives and inter-institutional programmes
- 9.6 Innovation outlook: challenges and progress
-
10: Challenges and research directions in bioinformatics and biomarker discovery
- 10.1 Introduction
- 10.2 Better software
- 10.3 The clinical relevance of new biomarkers
- 10.4 Collaboration
- 10.5 Evaluating and validating biomarker models
- 10.6 Defining and measuring phenotypes
- 10.7 Documenting and reporting biomarker research
- 10.8 Intelligent data analysis and computational models
- 10.9 Integrated systems and infrastructures for biomedical computing
- 10.10 Open access to research information and outcomes
- 10.11 Systems-based approaches
- 10.12 Training a new generation of researchers for translational bioinformatics
- 10.13 Maximizing the uses of public resources
- 10.14 Final remarks
- Guest commentary (1) on chapter 10: Towards building knowledge-based assistants for intelligent data analysis in biomarker discovery
- Guest commentary (2) on chapter 10: Accompanying commentary on ‘challenges and opportunities of bioinformatics in disease biomarker discovery’
- References
- Index
Product information
- Title: Bioinformatics and Biomarker Discovery: "Omic" Data Analysis for Personalized Medicine
- Author(s):
- Release date: March 2010
- Publisher(s): Wiley
- ISBN: 9780470744604
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