Recent progress in omics technologies, including genomics, transcriptomics and proteomics, offers an unprecedented opportunity to measure molecular activity which underlies biomedical effects. Challenges remain to transform these measurements into solid knowledge about the human body in both health and disease. Bioinformatics is the science and practice of utilizing computer technology to handle the data used to address complex biomedical problems. The reconstruction of complex biomedical systems can be seen as an inverse problem, the solution of which usually relies on assumptions derived from prior knowledge. Thus, a two-way approach of biomedical investigations from top-down, and also from bottom-up, in an adaptive ...

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