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Bioinformatics for Biomedical Science and Clinical Applications by K-H Liang

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2

Genomics

Abstract:

The human genome is the blueprint of the human body. It encodes valuable yet implicit clues about our physical and mental health. Human health and diseases are affected by inherited genes and environmental factors. A typical example is cancer, thought to be a genetic disease, where a collection of somatic mutations drives the progression of the disease. Tracking the disease roots down to the DNA alphabet promises a clearer understanding of disease mechanisms. DNA alphabets may also serve as stable biomarkers, suggesting personalized estimates of disease risks or drug response rates. In this chapter, we explore techniques critical for the success of genomic data analysis. Special emphasis is placed on the adaptive exploration ...

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