Ribonucleic acids (RNA) are macromolecules with diverse cellular and biological functions, composed of linear chains of nucleotides. RNAs either serve as templates for protein synthesis, or play critical catalytic and regulatory roles. The abundance and activities of all RNAs in time and space, referred to as the transcriptome, offer a global perspective on molecular activity in cells, which jointly affect human physiology and pathology. Microarrays and next-generation sequencing are two major technological platforms for transcriptome studies. An integrative, systems level approach is introduced, aiming to establish the genetic cause of disease by analyzing RNA and DNA profiles concurrently using advanced computational ...

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