O'Reilly logo

Bioinformatics with Python Cookbook by Tiago Antao

Stay ahead with the world's most comprehensive technology and business learning platform.

With Safari, you learn the way you learn best. Get unlimited access to videos, live online training, learning paths, books, tutorials, and more.

Start Free Trial

No credit card required

Simulating selection

We will now perform an example of simulating selection with simuPOP. We will perform a simple case with dominant mutation on a single loci and also a complex case with two loci using epistatic effects. The epistatic effect will have a mutation on an SNP. This is required to confer advantage and another mutation on another SNP that adds up to the previous one (but does nothing on its own); this was inspired by the very real case of malaria resistance to the sulfadoxine/pyrimethamine drug, which always requires a mutation on the DHFR gene, which can be enhanced with a mutation on the DHPS gene; if you are interested in knowing more, refer to the Origin and Evolution of Sulfadoxine Resistant Plasmodium falciparum article from ...

With Safari, you learn the way you learn best. Get unlimited access to videos, live online training, learning paths, books, interactive tutorials, and more.

Start Free Trial

No credit card required