Bioinspired and Green Synthesis of Nanostructures

3Optimization of the Process Parameters to Develop Green-Synthesized Nanostructures with a Special Interest in Cancer Theranostics

Tathagata Adhikary¹, Chowdhury Mobaswar Hossain² and Piyali Basak¹*

¹School of Bioscience and Engineering, Jadavpur University, Kolkata, India

²Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, West Bengal, Nadia, India

Abstract

Green synthesis follows eco-friendly laboratory protocols to limit the use of synthetic chemicals. Several methods are adopted for green synthesizing nanocomposites with optimal balance between their efficacy and toxicity. Each technique involves different parameters that primarily influence the characteristics (e.g., in terms of its mean particle size, concentration, or polydispersity index) of the synthesized nanoparticles. Assessing bioactivities of the nanoparticles combined with physicochemical characterizations (such as dynamic light scattering, FTIR, UV-Vis spectroscopy, electron microscopy, etc.) helps a researcher to reach the optimized product. A reader gets an insight into the mechanisms underlying different green nanofabrication techniques and the effect of various factors in the fabrication process. Statistical models and other in silico approaches are frequently employed along with experimental data to ease the optimization. Although these techniques remain valid in optimizing the green synthesis of any nanomaterial, this article attempts to review the related reports ...