Polymer-Based Biocompatible Surface
Kai Yu, Guangzheng Gao and Jayachandran N. Kizhakkedathu
Centre for Blood Research, Department of Pathology and Laboratory Medicine,
University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
The performance of a material intended for biomedical applications depends on its
interfacial properties and reactions that occur when come in contact with biological
ﬂuids. Non-speciﬁc protein adsorption at the biomaterial interface is the ﬁrst
and critical event that initializes a cascade of host responses, including platelet
activation, blood coagulation, and complement activation.
have been used to prevent such non-speciﬁc interactions.
Coating or immobilization of surfaces with biomacromolecules such as
and anticoagulants like heparin
have been widely studied to-
wards this purpose. Another approach to overcome this problem is to coat the
surface with synthetic hydrophilic polymers
and this method has been used
as a anti-fouling treatment for a number of applications including biosensors
and drug delivery systems.
It was demonstrated that such coatings frequently
extend the life span of biomedical devices
and the circulation half life of drug
Several factors that affect the protein-repelling properties of polymer thin ﬁlms
on surface include the similarity of interfacial free energies of the polymer with
that of water, interaction of proteins with polymers through hydrophobic or charge
interactions and environmental factors such as temperature and pH.
case of neutral hydrophilic polymer grafted surfaces, the steric barrier due to
high conformational entropy of anchored chains is one of the contributing factor
towards protein repulsion.
Other factors include, the structure of the polymer
Biomaterials for MEMS, Edited b y M. Chiao and J.-C. Chiao
Copyright © 2011 by Pan Stanford Publishing Pte. Ltd.
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