Figure 8.22. Fluorescence photographs of BSA-adsorbed (a) bare gold and (b) linear
mPEG-2000-, (c) linear mPEG-5000-, (d) low molecular weight HPG-SH-L-, and (e) high
molecular weight HPG-SH-H grafted surfaces. Polymer ﬁlms were produced by incubating
the gold surface in polymer solution at 6 g/L for 16 h. (f) Effect of the graft density on the
BSA adsorption of mPEG-, HPG-SH-L-,and HPG-SH-H-grafted surfaces. Images adapted
from Ref. 120. For color reference, see page 272.
molecular weight or lower molecular weight HPG. With increasing graft density
of the HPG chains on the surface, the protein adsorption was decreased( Fig. 8.22).
Our results show that HPG could be a good alternative to PEG in the development
of nonfouling functional surfaces.
8.7 PEPTIDE AND PROTEIN GRAFTED POLYMERIC SURFACES
There are lots of interests in recent years in the development of surfaces with
speciﬁc interaction to a certain biological system.
Short chain peptides or protein
coupled surfaces were used for this purpose.
Although there are several tech-
niques reported for the immobilization of peptides or proteins on the surface,
we will conﬁne our discussion on the use of non-fouling polymer surfaces synthe-
sized by surface initiated polymerization in this section.
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