Biomaterials for MEMS

References 197

Figure 8.26. Fabrication of protein-functionalized polymer brushes: (i) grafting of ATRP

initiator 1 and surface-initiated ATRP; (ii) activation of hydroxyl groups with p-nitrophenyl

chloroformate (NPC); (iii) functionalization with benzylguanine derivative 2and quenching

of residual NPC groups; (iv) immobilization of AGT fusion proteins on benzylguanine-

displaying surfaces. Images adapted from ref.

129

For color reference, see page 273.

8.8 CONCLUSIONS

We have made attempt to discuss the different approaches used in the devel-

opment of non-fouling surfaces based on polymeric surface modification. We

have also discussed the advantages and disadvantages of different methods

used for making non-fouling surfaces. Among the polymeric systems described,

poly(ethylene glycol) accounts for the majority of the non-fouling surfaces re-

ported literature. Covalent grafting of polymers especially surface initiated poly-

merization is gaining popularity due to the excellent stability of grafted layers

and non-fouling properties. There is lot of interest in the functionalization of

non-fouling surfaces especially for applications in immunoassays, biosensors and

microarrays.

ACKNOWLEDGEMENTS

J.N.K. acknowledges the financial support from University of British Columbia,

Canadian Blood Services, Canadian Institutes of Health Research and Natural

Science and Engineering Research Council of Canada (NSERC) and Canada Foun-

dation for Innovation (CFI). The is the recipient of a Canadian Institutes of Health

Research (CIHR)/Canadian Blood Services (CBS) new investigator award in trans-

fusion science KY acknowledges a postdoctoral fellowship from CBS/CIHR.

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