Bioprocess Engineering: Basic Concepts, 3rd Edition

9. Operating Considerations for Bioreactors for Suspension and Immobilized Cultures

So far, we have discussed what cells are, how they work, and how to describe their growth in simple reactors. We now begin our discussion of how to use these cells in industrial processes. This chapter explores some complicated reactor strategies and why they might be considered for use in real processes. Chapter 10, “Selection, Scale-Up, Operation, and Control of Bioreactors,” gives more details on reactor design, and Chapter 11, “Recovery and Purification of Products,” details how to recover products from these reactors. These chapters provide an understanding of how real bioprocesses can be assembled.

An important decision for constructing any process concerns ...