Bioprocess Engineering: Basic Concepts, 3rd Edition

14. Utilizing Genetically Engineered Organisms

In Chapter 8, “How Cellular Information Is Altered,” we discussed how cells could be genetically engineered. The techniques of genetic engineering are fairly straightforward; the design of the best production system is not. The choice of host cell, the details of the construction of the vector, and the choice of promoter must all fit into a processing strategy. That strategy includes plans not only for efficient production but also for how a product is to be recovered and purified. The development of processes for making products from genetically engineered organisms requires that many choices should be evaluated. Any choice at the molecular level imposes processing constraints. As indicated in ...