Computation in BioInformatics

1Bioinfomatics as a Tool in Drug Designing

Rene Barbie Browne, Shiny C. Thomas and Jayanti Datta Roy*

Department of BioSciences, Assam Don Bosco University, Sonapur, Assam, India

Abstract

Drug discovery is the method of identifying and validating a disease target and discovering and developing a chemical compound which can interact with its specific target. This process is very complex and time consuming, requiring multidisciplinary expertise and innovative approaches. To overcome the difficulties and complexity, in silico approach is used that reduces the time and expenditure. This chapter addresses the importance of bioinformatics in drug designing. It focuses on bioinformatics tools like AutoDock, LigPlot, FlexX, and many other softwares which play an important role in rational designing of drug. Thus, the main goal of this chapter is to provide an overview of the importance of bioinformatics tools in designing a drug.

Keywords: AutoDock, LigPlot, FleX, GenBank, SWISS-PROT, PDB

1.1 Introduction

Bioinformatics is a multidisciplinary field of life sciences merging biology, computer science, and information technology into a single discipline [1]. A wide range of subject areas is included in this field. These subject areas are structural biology, gene expression studies, and genomics. Computational techniques play an important role analyzing information that are associated with biomolecules on a large scale [2].

The main goal of bioinformatics aims toward better understanding ...