Computation in BioInformatics

12Genomic Association of Polycystic Ovarian Syndrome: Single-Nucleotide Polymorphisms and Their Role in Disease Progression

Gowtham Kumar Subbaraj*^† and Sindhu Varghese^†

Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education (Deemed to be University), Old Mahabalipuram Road, Kelambakkam, Tamil Nadu, India

Abstract

Polycystic ovary syndrome is the frequent and a multifaceted female endocrine disorder and is one of the prominent causes of female infertility. It is also known to be a typical syndrome among South Indian women initiating high risk of infertility. Here, the aim was to explore the relationship of single-nucleotide polymorphism of FSHR, IL-10, and IRS1 gene in the pathogenesis of PCOS. A hospital-based pilot case control study was carried on PCOS and control women in the tertiary care hospital. Genotype was carried out by polymerase chain reaction. The odds ratio was calculated and it was found to be 0.71, 1.06, and 0.32 for the genes and 95% CI was estimated to assess the relative risk. The relative possibility was found to be 0.72, 1.05, and 0.35, respectively. Thus, our findings suggested no association of FSHR (rs6166), whereas IL10 (rs1800896) showed a positive association with the PCOS condition. While IRS-1 (rs1801278) polymorphisms showed a negative association and these findings should be interpreted with caution. Though, the number of investigations in different population should absolutely ...