Computer-aided biopharmaceutical characterization: gastrointestinal absorption simulation

Sandra Grbic, Jelena Parojcic and Zorica Djuric,     Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade


This chapter introduces the concept of gastrointestinal absorption simulation using in silico methodology. Parameters used for model construction and the sensitivity predicted pharmacokinetic responses to various input parameters are described. Virtual trials for in silico modeling of drug absorption are presented. The influence of food on drug absorption, as well as correlation between the in vitro and in vivo results, are also addressed, followed by biowaiver considerations. Numerous examples ...

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