Computer-Aided Applications in Pharmaceutical Technology

List of figures

1.1. QbD approach, combining design space development and risk management tools  4

3.1. Three-level full factorial design for 3 factors, 3³ designs with 27 experiments  37

3.2. Experimental points for the mixture design  43

3.3. Three most commonly used mixture designs for three- component mixtures supporting linear (left), quadratic (center), and special cubic (right) models  44

3.4. Response surface plot showing effect of chitosan and sodium alginate concentration on encapsulation efficiency  54

4.1. PCA of the 4 sample 2 variables data set 61 Score and score contributions plot  79

4.2. Loading plot representing relationships among variables  80

4.3. Scores and loadings plot  82

4.4. Different arrangements of the data   ...