O'Reilly logo

Computer-Aided Vaccine Design by S. Ranganathan, J Tong

Stay ahead with the world's most comprehensive technology and business learning platform.

With Safari, you learn the way you learn best. Get unlimited access to videos, live online training, learning paths, books, tutorials, and more.

Start Free Trial

No credit card required

1

MHC and T cell responses

Abstract:

The major histocompatibility complex (MHC) molecules of classes I and II, coded by the human leukocyte antigen (HLA) genes on chromosome 6, are cell surface glycoproteins that play a major role in T cell-mediated immune recognition. Class I molecules are found on the surface of virtually all nucleated cells in humans, except neurons, and are involved in detection of viral infections in cells. Class II molecules are limited to specific antigen presenting cells. In both cases, T cell antigen recognition is triggered by the MHC presenting a short antigenic peptide fragment which binds to a specific T cell receptor (TCR) on the surface of T cells. In this chapter, we survey the nature of the MHC molecules and ...

With Safari, you learn the way you learn best. Get unlimited access to videos, live online training, learning paths, books, interactive tutorials, and more.

Start Free Trial

No credit card required