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Computer-Aided Vaccine Design by S. Ranganathan, J Tong

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5

Computational T cell vaccine design

Abstract:

T cell vaccines contain subsequences of an antigen that can induce protective T cell responses in the body. This type of vaccine is generally safer than live, attenuated vaccine, which may undergo secondary mutation in the body and revert to a virulent form. T cell vaccines can also stimulate a stronger immune response than inactivated vaccines, since they contain the specific parts of the antigen that can be recognized by T cells. However, identifying the antigens that best stimulate T cell responses is non-trivial. More than 7000 HLA alleles are deposited in the IMGT/HLA Database. Since an individual may possess up to six different HLA class I and class II alleles, the theoretical number of ...

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