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Computer-Aided Vaccine Design by S. Ranganathan, J Tong

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8

Vaccine safety and quality assessments

Abstract:

A pharmaceutical compound must be absorbed, distributed into the tissues, metabolized by specialized enzymes and finally excreted from the body (absorption, distribution, metabolism and excretion – ADME). Genetic variability in drug metabolizing enzymes may cause toxicity in some individuals (Tox). It is therefore necessary to carry out preclinical evaluation before testing a compound in humans. Similarly to other pharmaceutical products, vaccines must be carefully assessed for their safety and effectiveness before phased trials with humans are performed. Factors such as compound size, aqueous solubility, ionizability and lipophilicity can give information on "drug-likeness," and potential ...

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