Deep Learning Tissue Segmentation in Cardiac Histopathology Images
Jeffrey J. Nirschl⁎; Andrew Janowczyk†; Eliot G. Peyster⁎; Renee Frank⁎; Kenneth B. Margulies⁎; Michael D. Feldman⁎; Anant Madabhushi† ⁎University of Pennsylvania, Philadelphia, PA, United States†Case Western Reserve University, Cleveland, OH, United States
Abstract
Cardiac biopsies are obtained for the diagnosis of acute heart failure as well as post-heart-transplant rejection. On histology, both are characterized by an expansion of the cellular and acellular stromal tissue as well as morphologic changes within myocytes, among other features. There is growing evidence, from a number of diseases, that computer-extracted features of tissue and nuclear architecture ...
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