Chapter 8

Deep Learning Tissue Segmentation in Cardiac Histopathology Images

Jeffrey J. Nirschl; Andrew Janowczyk; Eliot G. Peyster; Renee Frank; Kenneth B. Margulies; Michael D. Feldman; Anant Madabhushi    University of Pennsylvania, Philadelphia, PA, United StatesCase Western Reserve University, Cleveland, OH, United States


Cardiac biopsies are obtained for the diagnosis of acute heart failure as well as post-heart-transplant rejection. On histology, both are characterized by an expansion of the cellular and acellular stromal tissue as well as morphologic changes within myocytes, among other features. There is growing evidence, from a number of diseases, that computer-extracted features of tissue and nuclear architecture ...

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