1Introduction

The analysis of a complex process requires the identification of target quality attributes that characterize the output of the process and of factors that may be related to those attributes. Once a list of potential factors is identified from subject-matter expertise, the strengths of the associations between those factors and the target attributes need to be quantified. A naïve, one-factor-at-a-time analysis would require many more trials than necessary. Additionally, it would not yield information about whether the relationship between a factor and the target depends on the values of other factors (commonly referred to as interaction effects between factors). As demonstrated in Douglas Montgomery’s Design and Analysis of Experiments ...

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