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Discovery of Novel Natural Products with Therapeutic Potential by Vincent P. Gullo

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CHAPTER 1

Aerobic Actinomycetes: A Continuing Source of Novel Natural Products

Ann C. Horan

Publisher Summary

This chapter describes the importance of aerobic actinomycetes as a continuing source of novel natural products. The micromonosporae have been crucial to the success of the Natural Products Program at Schering-Plough. The exploitation of these bacteria proved that nonstreptomycetes were valuable sources of novel natural products. Micromonosporae are the second largest group of actinomycetes in soil, surpassed only by the streptomycetes. They have been isolated from a variety of habitats. Jensen isolated micromonosporae from dry, neutral, and alkaline soils. They are found to be widely distributed, occurring preferentially in moist ...

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