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Discovery of Novel Natural Products with Therapeutic Potential by Vincent P. Gullo

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CHAPTER 2

Bacteria As a Source of Novel Therapeutics

J.C. Hunter–Cevera and Angela Belt

Publisher Summary

This chapter discusses the bacteria as a source of novel therapeutics. In a study described in the chapter, Gluconobacter and Acetobacter species isolated from 41 samples were the two genera most frequently found to produce monobactams and were, therefore, positive in the Colworth agar droplet/B-lactamase screen for related beta lactams. The isolation methods that incorporated natural extract and low pH isolation media did favor development of these colony types. These strains produced acid and still maintained metabolic activity at low pH. The fermentation media was not buffered and thus, it can be hypothesized that low pH may trigger ...

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