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Discovery of Novel Natural Products with Therapeutic Potential by Vincent P. Gullo

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CHAPTER 3

Potential of Fungi in the Discovery of Novel, Low-Molecular Weight Pharmaceuticals

M.M. Dreyfuss and I.H. Chapela

Publisher Summary

This chapter focuses on the potential of fungi in the discovery of novel, low-molecular weight pharmaceuticals. Although the estimated 3000 to 4000 known fungal secondary metabolites have been isolated after screening hundreds of thousands of fungal cultures, possibly not more than 5000 to 7000 taxonomic species have been studied in this respect, the latter being the number of fungal species maintained in culture collections throughout the world and representing, therefore, fungal species that can be readily grown in axenic culture. There are well-known fungal groups that resist artificial cultivation ...

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