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Discovery of Novel Natural Products with Therapeutic Potential by Vincent P. Gullo

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CHAPTER 7

Strategies for Discovering Antiviral Agents from Natural Products

E. Rozhon, R. Albin and J. Schwartz

Publisher Summary

This chapter discusses the strategies for discovering antiviral agents from natural products. The goal of a screening assay is to discover an agent that acts on a specific viral process, which results in the inhibition of production of infectious particles. This approach is possible for some viruses as sufficient information is known about viral-mediated events occurring after infection of the host cell that allow specific processes to be selected as targets for the action of antiviral agents. The identification of a naturally occurring agent that affects a specific viral process depends on the ability of the assay ...

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