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Discovery of Novel Natural Products with Therapeutic Potential by Vincent P. Gullo

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CHAPTER 8

Mechanism-Based Screens in the Discovery of Chemotherapeutic Antibacterials

Sunil Kadam

Publisher Summary

This chapter describes the mechanism-based screens in the discovery of chemotherapeutic antibacterials. A successful broad-based screening strategy typically involves an interdisciplinary, multistep process, combining at least five major areas and microbiology, fermentation, chemistry, molecular biology, and data management. As a consequence, a screening program has to be collaborative, automated, and technologically flexible to accept the continuous influx of new assays and methodology. The degree of success of a screening program is not solely dependent on the number of screens or size of its infrastructure but also on the ...

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