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Discovery of Novel Natural Products with Therapeutic Potential by Vincent P. Gullo

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CHAPTER 9

Oncogene Function Inhibitors of Microbial Origin

Kazuo Umezawa

Publisher Summary

This chapter discusses the oncogene function inhibitors of microbial origin. Streptomyces and other microorganisms produce antibiotics, anticancer agents, and enzyme inhibitors as secondary metabolites. Therefore, microorganisms are a treasury of organic compounds that have various structures and biological activities. Isolation of the specific bioactive products in culture broths depends on the testing method. As oncogene theory has been extensively developed in the field of carcinogenesis research, oncogene function inhibitors have been screened as a new group of microbial secondary metabolites. The EGF-receptor-associated tyrosine kinase was reported ...

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