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Discovery of Novel Natural Products with Therapeutic Potential by Vincent P. Gullo

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CHAPTER 12

Immunomodulators

Masakuni Okuhara and Toru Kino

Publisher Summary

This chapter describes the screening for immunosuppressants. There are several types of cells responsible for specialized functions in the immune system that act through hormone-like substances, much as in the nervous system. It was found that T cells could be cultured indefinitely in the presence of immunological hormone interleukin 2. It has been demonstrated time and again that this interleukin plays a crucial role in the immune response. On the one hand, the immune system protects the body against diseases from invasion by foreign organisms, but on the other hand, it can attack a lifesaving organ transplant or mistakenly respond to the body’s own molecules that, ...

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