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Discovery of Novel Natural Products with Therapeutic Potential by Vincent P. Gullo

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CHAPTER 13

Isolation and Purification of Secondary Metabolites

James B. McAlpine and Jill E. Hochlowski

Publisher Summary

This chapter discusses the isolation and purification of secondary metabolites. Secondary metabolites, by virtue of their nature as idiosyncratic and of no vital significance to the producing organism, are often produced in very low yields by the original wild type strains. The isolation and identification of new secondary metabolites for the sake of discovering novel structure per se is no longer an activity for which there is much support, either in academic or industrial laboratories. Most natural product chemistry is directed at some biological screen and the purification process tends to follow a bioactivity-directed ...

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