To determine how Domino will fit into your existing infrastructure, you have to consider the following issues:
How will you use Domino, both short-term and long-term? Will you use Domino companywide or just departmentally? Will people outside the company (suppliers, business partners, customers) have access to your servers?
How will Domino integrate into your existing network infrastructure?
What hardware and software upgrades to existing systems will be required to accommodate Domino?
What corporate culture exists now? Will collaboration require a shift in the way a company does business?
Who will drive the adoption of the project? Can you identify executives or influential persons in the company ...