Drug-Biomembrane Interaction Studies

Figures

1.1. The fluid mosaic model of cell membranes 6

1.2. Movement of lipids within the cell membrane bilayers 8

1.3. Structure of phospholipids and related compounds 10

1.4. Structure of PL bilayers 11

1.5. A general PL: a saturated (linear) and an unsaturated acyl chain are shown 12

1.6. Conformation of the hydrophobic domain in bilayers produced by PLs 13

1.7. Assembly of PLs into bilayers as a function of temperature 15

1.8. Different ways in which proteins can associate with the plasma membrane 18

1.9. Chemical structure of cholesterol 19

1.10. Position of CHOL molecules within a PL bilayer 19

1.11. The spontaneous diffusion path of an external lipophilic molecule through and across the lipid domains of membrane bilayers 25

1.12.  ...