Electrospinning for Tissue Regeneration

Electrospinning for Tissue Regeneration

by L Bosworth, S Downes
Released June 2011
Publisher(s): Woodhead Publishing
ISBN: 9780857092915

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Book description

Electrospinning is a simple and highly versatile method for generating ultrathin fibres with diameters ranging from a few micrometres to tens of nanometres. Although most commonly associated with textile manufacturing, recent research has proved that the electrospinning technology can be used to create organ components and repair damaged tissues. Electrospinning for tissue regeneration provides a comprehensive overview of this innovative approach to tissue repair and regeneration and examines how it is being employed within the biomaterials sector.

The book opens with an introduction to the fundamentals of electrospinning. Chapters go on to discuss polymer chemistry, the electrospinning process, conditions, control and regulatory issues. Part two focuses specifically on electrospinning for tissue regeneration and investigates its uses in bone, cartilage, muscle, tendon, nerve, heart valve, bladder, tracheal, dental and skin tissue regeneration before concluding with a chapter on wound dressings. Part three explores electrospinning for in vitro applications. Chapters discuss cell culture systems for kidney, pancreatic and stem cell research.

With its distinguished editors and international team of expert contributors, Electrospinning for tissue regeneration is a valuable reference tool for those in academia and industry concerned with research and development in the field of tissue repair and regeneration.

  • Provides a comprehensive overview of this innovative approach to tissue repair and regeneration covering issues from polymer chemistry to the regulatory process
  • Examines employment within the biomaterials sector, reviewing extensive applications in areas such as uses in bone, muscle tendon, heart valve and tissue regeneration
  • Explores electrospinning for in vitro applications and discusses cell culture systems for kidney, pancreatic and stem cell research

Table of contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. Contributor contact details
  6. Part I: Fundamentals of electrospinning
    1. Chapter 1: Introduction to electrospinning
      1. Abstract:
      2. 1.1 Introduction
      3. 1.2 Basic concepts
      4. 1.3 Morphology and structural formation
      5. 1.4 Parameters
      6. 1.5 Apparatus
      7. 1.6 Materials
      8. 1.7 Applications
      9. 1.8 Future trends
    2. Chapter 2: Polymer chemistry
      1. Abstract:
      2. 2.1 Introduction
      3. 2.2 Natural polymers
      4. 2.3 Synthetic degradable polymers
      5. 2.4 Conclusions
    3. Chapter 3: The electrospinning process, conditions and control
      1. Abstract:
      2. 3.1 Introduction
      3. 3.2 Solution parameters
      4. 3.3 Processing parameters
      5. 3.4 Ambient parameters
      6. 3.5 Conclusions
    4. Chapter 4: Regulatory issues relating to electrospinning
      1. Abstract:
      2. 4.1 Introduction
      3. 4.2 Regulation of materials in regenerative medicine
      4. 4.3 Future trends
      5. 4.4 Sources of further information and advice
  7. Part II: Electrospinning for tissue regeneration
    1. Chapter 5: Bone tissue regeneration
      1. Abstract:
      2. 5.1 Introduction
      3. 5.2 Principles of bone biology
      4. 5.3 Strategies for bone regeneration
      5. 5.4 Fabrication of scaffolds for bone tissue engineering
      6. 5.5 Potential materials for scaffolds
      7. 5.6 Osteoporosis: a growing problem
      8. 5.7 Strategies for the treatment of bone defects
      9. 5.8 Conclusions and future trends
    2. Chapter 6: Cartilage tissue regeneration
      1. Abstract:
      2. 6.1 Introduction
      3. 6.2 Culture of chondrogenic cells for implantation
      4. 6.3 Electrospun nanofibre scaffolds
      5. 6.4 Future trends
    3. Chapter 7: Muscle tissue regeneration
      1. Abstract:
      2. 7.1 Introduction to skeletal muscle
      3. 7.2 Skeletal muscle injuries
      4. 7.3 Mechanical properties of skeletal muscle
      5. 7.4 Tissue engineering
      6. 7.5 Contractile force
      7. 7.6 Conductive elements
      8. 7.7 Conclusion and future trends
    4. Chapter 8: Tendon tissue regeneration
      1. Abstract:
      2. 8.1 Introduction: tendon tissue
      3. 8.2 Tendon structure and composition
      4. 8.3 Tendon pathology
      5. 8.4 Clinical need
      6. 8.5 Tissue engineering
      7. 8.6 Cell response to electrospun bundles
      8. 8.7 Mechanical properties of electrospun bundles
      9. 8.8 Conclusions and future trends
      10. 8.9 Acknowledgements
    5. Chapter 9: Nerve tissue regeneration
      1. Abstract:
      2. 9.1 Introduction
      3. 9.2 Clinical problems in nerve tissue therapy
      4. 9.3 Nerve tissue engineering
      5. 9.4 Biomimetic nanoscaffolds for peripheral nerve regeneration
      6. 9.5 Stem cell therapy with nanofibre for nerve regeneration
      7. 9.6 Conclusion and perspectives
    6. Chapter 10: Heart valve tissue regeneration
      1. Abstract:
      2. 10.1 Introduction
      3. 10.2 Tissue to be replaced: heart valves
      4. 10.3 Specific tissue requirements as a blueprint for scaffold properties
      5. 10.4 Selection of scaffold material
      6. 10.5 Scaffold properties to meet tissue requirements
      7. 10.6 Future trends
      8. 10.7 Acknowledgment
    7. Chapter 11: Bladder tissue regeneration
      1. Abstract:
      2. 11.1 Structural/functional properties of the bladder
      3. 11.2 Bladder disease and the need for bladder substitution
      4. 11.3 Electrospun and other scaffolds for bladder tissue engineering
      5. 11.4 Electrospinning fit for purpose
      6. 11.5 Future trends
      7. 11.6 Conclusions
      8. 11.7 Acknowledgement
    8. Chapter 12: Tracheal tissue regeneration
      1. Abstract:
      2. 12.1 Anatomy of the trachea and main pathologies of surgical concern
      3. 12.2 Tissue engineered trachea (TET)
      4. 12.3 Electrospun biodegradable tubular tracheal scaffold
      5. 12.4 Scaffold fulfilment
      6. 12.5 In vitro and in vivo evaluation of the cell and tissue response
      7. 12.6 Conclusions
      8. 12.7 Acknowledgements
    9. Chapter 13: Dental regeneration
      1. Abstract:
      2. 13.1 Introduction
      3. 13.2 Periodontal regeneration
      4. 13.3 Reinforcement of dental restorations
      5. 13.4 Conclusions and future trends
    10. Chapter 14: Skin tissue regeneration
      1. Abstract:
      2. 14.1 Introduction
      3. 14.2 Biology of skin and wound healing
      4. 14.3 Challenging problems in existing therapies
      5. 14.4 Restoring functional skin tissue
      6. 14.5 Nanofibres as extracellular matrix analogue
      7. 14.6 Ideal properties of scaffold
      8. 14.7 Choice of biomaterial
      9. 14.8 Cellular interactions on skin substitute
      10. 14.9 Conclusions and future trends
    11. Chapter 15: Wound dressings
      1. Abstract:
      2. 15.1 Introduction: wound healing
      3. 15.2 Nanofibres
      4. 15.3 Antimicrobial nanofibrous wound dressings
      5. 15.4 Conclusions
  8. Part III: Electrospinning for in vitro applications
    1. Chapter 16: Cell culture systems for kidney research
      1. Abstract:
      2. 16.1 Introduction
      3. 16.2 Current work
      4. 16.3 Electrospun materials
      5. 16.4 Scanning electron microscopy of cells on electrospun scaffolds
      6. 16.5 Immunostaining of extracellular matrix proteins on electrospun scaffolds
      7. 16.6 Immunostaining of cells on electrospun scaffolds
      8. 16.7 Comparison of culture methods
      9. 16.8 Discussion and future trends
      10. 16.9 Acknowledgements
    2. Chapter 17: Cell culture systems for pancreatic research
      1. Abstract:
      2. 17.1 Introduction
      3. 17.2 Min6 cell line
      4. 17.3 Nes2y cells
      5. 17.4 Novel scaffolds and production methods
      6. 17.5 Methods
      7. 17.6 Results
      8. 17.7 Discussion
      9. 17.8 Future trends
      10. 17.9 Conclusion
    3. Chapter 18: Cell culture systems for stem cell research
      1. Abstract:
      2. 18.1 Introduction
      3. 18.2 Embryonic stem cells
      4. 18.3 Current culture techniques
      5. 18.4 3D scaffolds
      6. 18.5 Combining ES cells with electrospun scaffolds
      7. 18.6 Future trends
  9. Index

Product information

  • Title: Electrospinning for Tissue Regeneration
  • Author(s): L Bosworth, S Downes
  • Release date: June 2011
  • Publisher(s): Woodhead Publishing
  • ISBN: 9780857092915